Response to trauma and metabolic changes: posttraumatic metabolism
Turgay Şimşek1, Hayal Uzelli Şimşek2, Nuh Zafer Cantürk3
1Clinic of General Surgery, Sakarya Toyotasa Emergency Service Hospital, Sakarya, Turkey
2Department of Obstetrics and Gynaecology Sakarya University Training and Research Hospital, Sakarya, Turkey
3Department of General Surgery, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
Abstract
Stress response caused by events such as surgical trauma includes endocrine, metabolic and immunological changes. Stress hormones and cytokines play a role in these reactions. More reactions are induced by greater stress, ultimately leading to greater catabolic effects. Cuthbertson reported the characteristic response that occurs in trauma patients: protein and fat consumption and protection of body fluids and electrolytes because of hypermetabolism in the early period. The oxygen and energy requirement increases in proportion to the severity of trauma. The awareness of alterations in amino acid, lipid, and carbohydrate metabolism changes in surgical patients is important in determining metabolic and nutritional support. The main metabolic change in response to injury that leads to a series of reactions is the reduction of the normal anabolic effect of insulin, i.e. the development of insulin resistance. Free fatty acids are primary sources of energy after trauma. Triglycerides meet 50 to 80 % of the consumed energy after trauma and in critical illness. Surgical stress and trauma result in a reduction in protein synthesis and moderate protein degradation. Severe trauma, burns and sepsis result in increased protein degradation. The aim of glucose administration to surgical patients during fasting is to reduce proteolysis and to prevent loss of muscle mass. In major stress such as sepsis and trauma, it is important both to reduce the catabolic response that is the key to faster healing after surgery and to obtain a balanced metabolism in the shortest possible time with minimum loss. For these reasons, the details of metabolic response to trauma should be known in managing these situations and patients should be treated accordingly.
Keywords: Posttraumatic metabolism, stress response, trauma response
Externally peer-reviewed.
Concept - T.Ş., H.U.Ş., N.Z.C.; Design - T.Ş., H.U.Ş., N.Z.C.; Supervision - T.Ş., H.U.Ş., N.Z.C.; Literature Review - T.Ş., H.U.Ş., N.Z.C.; Writer - T.Ş., H.U.Ş., N.Z.C.; Critical Review - T.Ş., N.Z.C.
No conflict of interest was declared by the authors.
The authors declared that this study has received no financial support.