Rıza Haldun Gündoğdu1, Uğur Yaşar2, Pamir Eren Ersoy1, Emre Ergül3, Semra Işıkoğlu4, Atilla Elhan5

1Clinic of General Surgery, Atatürk Training and Research Hospital, Ankara, Turkey
2Clinic of General Surgery, Darende Hulusi Efendi State Hospital, Malatya, Turkey
3Clinic of General Surgery, Dr. Hulusi Alataş Elmadağ Hospital, Ankara, Turkey
4Afyon Public Health Laboratory, Biochemistry, Afyon, Turkey
5Department of Biostatistics, Ankara University Faculty of Medicine, Ankara, Turkey


Objective: It has been proven that malnutrition increases postoperative morbidity and mortality, and it may also negatively affect wound healing in the gastrointestinal tract. In the literature, there is only one study evaluating the effects of preoperative nutritional support on colonic anastomotic healing under malnourished conditions. In order to improve the data on this topic, an experimental study was planned to evaluate the effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats.
Material and Methods: The study included 18 male Wistar albino rats divided into 3 groups. The control (C) group was fed ad libitum for 21 days. The malnutrition (M) group and preoperative nutrition (P) group were given 50% of the daily food consumed by the rats in Group C for 21 days to induce malnutrition. At the end of 21 days, Group P was fed ad libitum for 7 days (preoperative nutritional support). Colonic transection and end-to-end anastomosis was performed at 21 days in Group C and Group M and at 28 days in Group P. The rats were sacrificed at postoperative 4 days, anastomotic bursting pressure was measured, and samples were taken to analyze tissue hydroxyproline levels.
Results: Anastomotic bursting pressure was significantly higher in Group C than in Group M and Group P (p<0.05), and it was significantly higher in Group P than in Group M (p<0.05). Tissue hydroxyproline levels in Group P were found to be significantly higher than those in Group M and Group C (p<0.05).
Conclusion: One week of preoperative nutritional support increases collagen synthesis in the colon and positively affects anastomotic healing under malnourished conditions.

Keywords: Malnutrition, nutritional support, anastomotic healing


Ethics Committee Approval

Ethics committee approval was received for this study from the ethics committee of Animal Ethics Committee of Ankara Hospital.

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - R.H.G.; Design z- R.H.G., P.E.E.; Supervision - R.H.G., P.E.E.; Funding - R.H.G., U.Y.; Materials - R.H.G., U.Y.; Data Collection and/or Processing - U.Y., P.E.E., E.E.; Analysis and/or Interpretation - A.E., S.I.; Literature Review - R.H.G., U.Y.; Writer - R.H.G., U.Y.; Critical Review - R.H.G.

Conflict of Interest

No conflict of interest was declared by the authors.

Financial Disclosure

The authors declared that this study has received no financial support.