How to approach phyllodes tumors of the breast?
Turan Acar1, Ercüment Tarcan1, Mehmet Hacıyanlı1, Erdinç Kamer1, Mustafa Peşkersoy1, Seyran Yiğit2, Özlem Gür1, Necat Cin1, Ayşegül Akder Sarı2, Fatma Tatar1
Objective: Phyllodes tumor of the breast is a rare fibroepithelial breast tumor that comprise 0.3-0.9% of primary breast neoplasms. In this study, we aimed to present clinicopathologic symptoms of our patients along with their treatment modality.
Material and Methods: Clinicopathologic properties and treatment modality of 20 phyllodes patients who underwent surgery between January 2008 and January 2013 were retrospectively evaluated.
Results: Median patient age was 46.55 years (22-75). Fine-needle aspiration biopsy was applied to 19 patients. Biopsy results were reported as suspicious in four, malignant in three, benign in 11, and as non-diagnostic in one patient. Final histopathology reports revealed two benign, one malignant and one borderline tumor out of the four patients with suspicious findings on fine needle aspiration biopsy; all patients with malignant cytology had malignancy. There were two borderline and nine benign lesions within the benign biopsy group. Sixteen patients underwent segmental mastectomy, four patients underwent mastectomy with/without axillary dissection. The median tumor size was 6 (1-13) cm. Histopathologically, 11 (55%) tumors were benign, 5 (25%) were borderline, and 4 (20%) were malignant. Two of the four patients with malignancy underwent radiotherapy and chemotherapy, and one patient only received chemotherapy as adjuvant treatment.
Conclusion: Phyllodes tumors are rare, mix-type breast tumors. Due to high rates of local recurrence and potential for malignancy, preoperative diagnosis and accurate management are important.
Keywords: Phyllodes tumor, breast cancer, mastectomy
Ethics committee approval was received for this study from the ethics committee of İzmir Katip Çelebi University Atatürk Training and Research Hospital (Decision number: 168; Date: 02.08.2013).
Written informed consent was obtained from patients who participated in this study.
Concept - T.A., E.T., M.H., E.K., M.P., S.Y., Ö.G., N.C., A.A.S., F.T.; Design - T.A., E.T., M.H., E.K., M.P., S.Y., Ö.G., N.C., A.A.S., F.T.; Supervision - T.A., E.T., M.H., E.K., M.P., S.Y., Ö.G., N.C., A.A.S., F.T.; Funding - T.A., E.T.; Materials - T.A., S.Y., A.A.S.; Data Collection and/or Processing - T.A., E.K.; Analysis and/or Interpretation - T.A., E.T., M.H., E.K., M.P., S.Y., Ö.G., N.C., A.A.S., F.T.; Literature Review - T.A., E.T., M.H., E.K., M.P., S.Y., Ö.G., N.C., A.A.S., F.T.; Writer - T.A.; Critical Review - M.H., M.P.
No conflict of interest was declared by the authors.
The authors declared that this study has received no financial support.