Emel Canbay1,2, Bahar Canbay Torun3, Ege Sinan Torun4, Yutaka Yonemura1,2

1NPO HIPEC Istanbul, Centermed, İstanbul, Turkey
2NPO to Support Peritoneal Dissemination Treatment, 1-26 Harukimotomachi, Kishiwada City, Osaka, Japan
3Department of General Surgery, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
4Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey


Management of peritoneal surface malignancies has gradually evolved by the introduction of cytoreductive surgery in combination with intraperitoneal chemotherapy applications. Recently, peritoneal metastases of intraabdominal solid organ tumors and primary peritoneal malignancies such as peritoneal mesothelioma are being treated with this new approach. Selection criteria are important to reduce morbidity and mortality rates of patients who will experience minimal or no benefit from these combined treatment modalities. Management of peritoneal surface malignancies with this current trend is presented in this review.

Keywords: Heated chemotherapy, peritoneal metastases, colorectal cancer, gastric cancer, ovarian cancer, mesothelioma


Peer Review

This manuscript was prepared by the invitation of the Editorial Board and its scientific evaluation was carried out by the Editorial Board.

Author Contributions

Concept – E.C.; Design – E.C.; Supervision – Y.Y.; Data Collection and/or Processing – B.C.T., E.S.T.; Analysis and/or Interpretation – E.C.; Literature Search – E.C.; Writing Manuscript – E.C.; Critical Review – Y.Y.

Conflict of Interest

No conflict of interest was declared by the authors.

Financial Disclosure

The authors declared that this study has received no financial support.


The authors are grateful to Professor Haluk Kiper for his technical assistance in palliative interventions of five serious cases with peritoneal metastasis in Turkey.