Turkish Journal of Surgery

Turkish Journal of Surgery

ISSN: 2564-6850
e-ISSN: 2564-7032


Halil İbrahim Taşcı1, Mehmet Erikoğlu2, Hatice Toy3, Adnan Karaibrahimoğlu4

1Department of General Surgery, Reyhanli Public Hospital, Hatay, Turkey
2Department of General Surgery, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
3Department of Pathology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
4Department of Medical Statistics, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey


Objective: Numerous studies show the relationship between sepsis and thyroid hormones. Virtually all these studies investigate changes in post-sepsis thyroid hormones and the relationship between these changes and the progression of the disease. Our aim in this study was to investigate the progression of sepsis in rats with thyroid dysfunction.
Material and Methods: The study involved four groups, each containing seven female Wistar albino rats: Group 1: Sham, Group 2: Control (Sepsis), Group 3: Hyperthyroidism-Sepsis, and Group 4: Hypothyroidism-Sepsis. Group 1 only received laparotomy. Group 2 only had sepsis. Sepsis was induced in Group 3 and Group 4 following formation of hyperthyroidism and hypothyroidism, respectively. After 24 hours, relaparotomy and thoracotomy were performed, and tissue and blood samples were drawn.
Results: Dysfunctions seen in the liver, lungs, and kidneys during sepsis and other findings of sepsis were milder in the hyperthyroidism group in comparison to both the control and hypothyroidism groups.
Conclusion: The results of Simon’s grade, histopathological organ damage, and laboratory parameters revealed that the progression of sepsis was milder in the hyperthyroid group than in the hypothyroid and euthyroid groups. The progression in the hypothyroid group was the most severe. Therefore, the results of the study raise the question of whether immediate treatment in cases of hypothyroidism and slow return of thyroid function to normal levels in cases of hyperthyroidism are adequate treatment approaches in patients who may develop sepsis or septic shock.” To determine the answer to this question, more detailed studies are required with a higher number of subjects.

Keywords: Hyperthyroidism, hypothyroidism, organ dysfunction, sepsis

This study was presented at the 50th Congress of the European Society for Surgical Research, 10-13 June 2015, Liverpool, UK.

Cite this paper as: Taşcı Hİ, Erikoğlu M, Toy H, Karaibrahimoğlu A. Course of sepsis in rats with thyroid dysfunction. Turk J Surg 2017; 33: 175-179.


Ethics Committee Approval

Ethics committee approval was received for this study from the ethics committee of Necmettin Erbakan University KONUDAM Experimental Medicine Research and Study Center’s (date: 11.14.2014/decision no: 2014-056).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - H.I.T., M.E.; Design - H.I.T., M.E.; Supervision - H.I.T., M.E.; Materials - H.I.T., A.K.; Data Collection and/or Processing - H.I.T., A.K.; Analysis and/or Interpretation - H.I.T., A.K.; Literature Search - H.I.T.; Writing Manuscript - H.I.T., M.E.; Critical Reviews - H.I.T., M.E., A.K.

Conflict of Interest

No conflict of interest was declared by the authors.

Financial Disclosure

The authors declared that this study has received no financial support.