THE PROGNOSTIC VALUE OF TISSUE EXPRESSION OF BETA-HCG IN COLORECTAL CANCER

Abstract

The value of the b-HCG expression in biologic behavior of colorectal tumors is unclear. In this study, we aimed to evaluate the effect of expression of b-HCG on local tumor behavior and survival in the patients with colorectal cancer. Between 1989 and 1998, the medical record of the sixty colorectal carcinoma patients (35 male and 25 female) who underwent operation was reviewed. 21 pts (35%) were b-HCG positive, while 39 (65%) were negative according to established scoring system. c2 or Fisher exact test was used in comparision of pathologic data. The differences of survival analysis calculated by using log-rank and cox-regression test. There was no correlation between b-HCG expression and tumor grade, stage, invasion (lymphatic, peri-neural and venous) and differentiation rate (p >0.05). Disease free survival (DFS) and overall survival (OS) were 65 ± 11 months and 81 ± 11 months in b-HCG expression (+) group, respectively. DFS and OS were 78 ± 11 months and 85 ( 9 months in b-HCG expression group, respectively. Also in the same manner, DFS and OS were 45%, 55% in b-HCG expression (+) group, where as 54.55% in b-HCG expression (-) group for five years. There was no survival difference between b-HCG expression (+) and (-) group according to Cox regression analysis (p >0.05). According to our analysis, b-HCG expression was not significant for the definition of the local tumor behavior and survival in colorectal cancer patients.