İsmail Zihni1, Volkan Soysal1, Adam Uslu1, Baha Zengel1, Gökalp Okut1, Ahmet Aykas1, Ali Duran1, Erhan Tatar2

1Department of General Surgery, İzmir Bozyaka Research and Training Hospital, İzmir, Turkey
2Department of Nephrology, İzmir Bozyaka Research and Training Hospital, İzmir, Turkey


Objectives: The literature about the frequency of metabolic syndrome in patients with multinodular goitre and a new onset of metabolic syndrome after total thyroidectomy is limited. The aim of this study was to investigate the effects of total thyroidectomy and thyroid hormones on a new onset of metabolic syndrome in patients who underwent total thyroidectomy and have received thyroid hormone replacement.
Material and Methods: Fifty-nine patients who underwent total thyroidectomy for multinodular goitre were included in this prospective study. Patients’ height, weight, and waist circumference were measured, and the body mass index was calculated. Peripheral blood samples were obtained preoperatively and at the 12th and 24th month after total thyroidectomy to examine the lipid profile, glucose homeostasis, and thyroid function tests.
Results: The lipid profile and blood pressure parameters deteriorated, and the mean body mass index and waist circumference with the metabolic syndrome rates significantly increased at the 12th and 24th months follow-up. Preoperative body mass index (Exp[B] 1.60; p=0.003) was independently associated with metabolic syndrome at the 2nd year after total thyroidectomyin a multivariate regression analysis.
Conclusion: The frequency and severity of MetS is high in adult patients with non-toxic multinodular goitre after total thyroidectomy. The frequency of metabolic syndrome increased in patients with a high body mass index after total thyroidectomy.

Keywords: Metabolic syndrome, total thyroidectomy, subclinical hypothyroidism, body mass index

Cite this paper as: Zihni İ, Soysal V, Uslu A, Zengel B, Okut G, Aykas A, et al. Development of metabolic syndrome after bilateral total thyroidectomy despite the l-t4 replacement therapy: A prospective study. Turk J Surg 2018; 10.5152/turkjsurg.2018.3746.


Ethics Committee Approval

Authors declared that the research was conducted according to the principles of the World Medical Association Declaration of Helsinki “Ethical Principles for Medical Research Involving Human Subjects” (amended in October 2013).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - İ.Z., A.U.; Design - A.U.; Supervision - V.S., A.U.; Materials - B.Z., G.O.; Data Collection and/or Processing - B.Z., G.O., A.A.; Analysis and/or Interpretation - A.D. E.T.; Literature Search - E.T., A.U.; Writing Manuscript - İ.Z., A.U., E.T.; Critical Reviews - V.S., E.T.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.