Dinesh Chandra Doval1, Juhi Tayal2, Kumardeep Dutta Choudhary1, Pankaj Goyal1, Gurudutt Gupta3, Sunil Pasricha3

1Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
2Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
3Department of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India


Extraosseous sarcoma of the breast occurs infrequently and is a harbinger of poor prognosis. The histogenesis of this tumor is ambiguous, and it can arise both in de novo and metastatic settings. Morphologically, it is indistinguishable from its skeletal counterpart, and clinically, it presents similarly to any other subtype of breast cancer. Tumor recurrence with a propensity for hematogenous rather than lymphatic spread plagues this malicious disease. The treatment guidelines are mainly derived from the those of other extraskeletal sarcomas as the literature is limited in this context. We hereby present 2 clinical cases with similar clinical profiles and different treatment outcomes. The intent of this case report is to contribute to the limited database available for the management of this rare disease.

Keywords: Breast carcinoma, chemotherapy, extraosseous, mesenchymal, osteosarcoma, sarcomas

Cite this paper as: Doval DC, Tayal J, Choudhary KD, Goyal P, Gupta G, Pasricha S. Treatment conundrums in osteosarcoma of the breast: Two clinical cases from a tertiary care cancer center in India. Turk J Surg 2018; 10.5152/turkjsurg.2018.4075.


Peer Review

Externally peer-reviewed.

Author Contributions

Concept - D.C.C., T.J.; Design - J.T., K.D.C., P.G., G.G., S.P.; Supervision - D.C.C.; Resource - D.C.C.; Materials - K.D.C., P.G., G.G., S.P.; Data Collection and/or Processing - J.T., G.G., S.P.; Analysis and/or Interpretation - D.C.C., J.T.; Literature Search - J.T., K.D.C., P.G.; Writing Manuscript - D.C.C., J.T.; Critical Reviews - D.D.C., K.D.C.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.