Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

Abstract

Objectives: The aim of this study was to evaluate the effects of the change in the body mass index following laparoscopic sleeve gastrectomy on the vascular morphology structure and biochemical and hemocytic parameters.
Material and Methods: A prospective evaluation of 60 patients who underwent sleeve gastrectomy was conducted. The relationship was evaluated between the vascular morphological parameters and biochemical and hemocytic inflammatory variables of the patients preoperatively and at 6, 12, and 18 months postoperatively.
Results: Compared to the baseline values, a significant decrease was determined in the carotid intima media thickness at 6, 12, and 18 months (p<0.001, p<0.001, p<0.001, respectively). The compliance and distensibility values were observed to increase over time (p<0.05, p<0.001, p<0.001, respectively). A statistically significant difference was determined in the carotid intima media thickness values according to gender, with males (n:7) measuring 0.618±0.123 mm and females (n:53) measuring 0.506±0.113 mm (p<0.01). When patients were grouped as neutrophil-to-lymphocyte ratio ≤2.54 (n:41) and neutrophil-to-lymphocyte ratio>2.55 (n:19), the increasing neutrophil-to-lymphocyte ratio values were observed to be in proportion to the carotid intima media thickness, and the difference was statistically significant (p<0.001). When factors affecting the vascular morphology parameters measured at baseline and throughout the study were evaluated with the correlation analysis, there was observed to be a positive correlation between the baseline carotid intima media thickness thickness and neutrophil percentage (r=0.736, p<0.001) and neutrophil-to-lymphocyte ratio (r=0.676, p<0.001), and between the negative correlation and lymphocyte percentage (r=−0.628, p<0.001).
Conclusion: Laparoscopic sleeve gastrectomy is not only a cosmetic procedure reducing the body mass index values, but it also has a beneficiary effect on vascular morphology, biochemical, and hemocytic parameters.

Cite this paper as: Baykara M, Yazar FM, Cengiz E, Bülbüloğlu E. Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients. Turk J Surg 2018; 10.5152/turkjsurg.2018.3939.

Authors declared that the research was conducted according to the principles of the World Medical Association Declaration of Helsinki “Ethical Principles for Medical Research Involving Human Subjects” Informed Consent: Written informed consent was obtained from patients who participated in this study.

Externally peer-reviewed.

Concept - M.B., F.M.Y.; Design - E.C., M.B.,.; Supervision - E.B., F.M.Y.; Resource - M.B., F.M.Y., E.C.; Materials - E.B., F.M.Y., M.B.; Data Collection and/or Processing - M.B., F.M.Y., E.C.; Analysis and/or Interpretation - F.M.Y., M.B.; Literature Search - E.B., E.C.; Writing Manuscript - M.B., E.C.; Critical Reviews - E.B.

The authors have no conflicts of interest to declare.

The authors declared that this study has received no financial support.