Alireza Rastgoo Haghi1, Amir Kasraianfard2, Alireza Monsef1, Amin Shoa Kazemi1, Siavash Rahimi3, Seyed Mohammad Reza Javadi2

1Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Surgery, Hamadan University of Medical Sciences, Hamadan, Iran
3Department of Internal Medicine, Mazandaran University of Medical Sciences Ramsar Campus, Sari, Iran


Objective: Despite the recent use of computed tomography scan and diagnostic laparoscopy, acute appendicitis is still highly misdiagnosed. Timely diagnosis of acute appendicitis is more crucial in children and elderly patients because of vague symptoms and rapid progression to perforation in these age groups, which may result in high rates of morbidity and mortality. The aim of the present study was to find the diagnostic values of procalcitonin and interleukin 6 (IL-6) for diagnosing acute appendicitis in our center.
Material and Methods: Patients who were suspected of acute appendicitis and referred to the emergency department of a tertiary care urban hospital in 2016 were enrolled in the study. A 5 mL blood sample was obtained from each patient before appendectomy and was examined for procalcitonin and IL-6. Then the resected specimen of the appendix was studied by a pathologist, and a definite diagnosis was made.
Results: Eighty patients including 53 (66.3%) men who underwent appendectomy were enrolled in the study. The diagnosis of acute appendicitis was histopathologically confirmed in 60 (75%) patients including 18, 20, and 22 patients with inflammatory, suppurative, and gangrenous/perforated appendicitis, respectively. The sensitivity and specificity of procalcitonin versus IL-6 for diagnosing acute appendicitis were 65% and 80% vs. 76% and 55%, respectively. The sensitivity and specificity of concurrent procalcitonin and IL-6 for diagnosing acute appendicitis were 95% and 55%, respectively.
Conclusion: Our study suggests that parallel measurement of procalcitonin and IL-6 decreases unnecessary negative appendectomies.

Keywords: Appendicitis, interleukin 6, procalcitonin

Cite this article as: Rastgoo Haghi A, Kasraianfard A, Monsef A, Kazemi AS, Rahimi S, Javadi SMR. The diagnostic values of procalcitonin and interleukin 6 in acute appendicitis. Turk J Surg 2019; 35 (1): 19-22


Ethics Committee Approval

Ethics committee approval was received for this study from the Ethics Committee of Hamadan University of Medical Sciences.

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - A.R.H., S.M.R.J., A.M.; Design - A.R.H., S.M.R.J., A.S.K.; Supervision - A.R.H., A.K., S.M.R.J.; Resource - A.R.H., S.M.R.J., A.M.; Materials - A.R.H., A.K., A.M.; Data Collection and/or Processing - A.K., S.R., A.S.K.; Analysis and/or Interpretation - A.R.H., A.S.K., A.K.; Literature Search - S.M.R.J., A.M., A.K.; Writing Manuscript - A.K., S.R., A.S.K.; Critical Reviews - A.R.H., S.M.R.J., A.M.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.