THE EFFECT OF DIFFERENT INTRAABDOMINAL PRESSURES ON BACTERIAL TRANSLOCATION

Abstract

In this experimental study we aimed to investigate the effect of different intraabdominal pressure (IAP) levels to bacterial translocation (BT), Increased intraabdominal pressure may give rise to various pathophysiological events which may progress to even multiple organ failure. It was clearly demostrated that the development of abdominal compartment syndrome (ACS) increases mortality and morbidity. Most of the recent studies have investigated the early stage physiologic events and focused on early treatment modalities, in this study we used a total of 36 rats divided into 6 groups. First group of rats were only underwent o laparotomy (sham operation). An intraabdominal pressure of 14, 15,17,19 and 21mmHg was established by intraperitoneal isotonic saline infusion in the second, third, fourth, fifth and sixth groups respectively. Groups were underwent a laparotomy and ileoceacal lymph node, spleen and liver biopsies were taken for the evaluation of BT, It was observed that BT has occured in all groups in various degrees. BT, measured by qualitative means, was found to be close for statistically significant value among the 5th and 6th groups and 1st and second groups. For a guantitative evaluation further ten rats were divided into two groups and an IAP of 14 and 19 mmHg was created. In the second phase of this study the development of BT was expressed in cfu/gr. IAP of 15 mmHg, emerges BT and this finding becomes evident when the pressure reaches to the level of 19 mmHg. This level of pressure showed a significant difference when compared with the control and 14 mmHg pressure groups. We concluded that these pressure values suggests an intravesical pressure monitoring could be a valuable diagnostic tool for the prevention and management of the ACS.