Evaluation of the efficacy of platelet-rich plasma in preventing postoperative intraabdominal adhesions
Ersin Turan1, Barış Ayhan2, Süleyman Kargın3, Osman Doğru4, Nevzat Serdar Uğraş5
1Clinic of General Surgery, Beyhekim State Hospital, Konya, Turkey
2Clinic of General Surgery, Private Akademi Hospital, Konya, Turkey
3Department of General Surgery, KTO Karatay University School of Medicine, Konya, Turkey
4Clinic of General Surgery, Konya Training and Research Hospital, Konya, Turkey
5Department of General Surgery, Selcuk University School of Medicine, Konya, Turkey
Objective: Postoperative intraabdominal adhesions still maintain their currency as serious causes of morbidity and mortality. This study aimed at evaluating the role of platelet-rich plasma (PRP) in the prevention of intraabdominal adhesions.
Material and Methods: A total of 16 healthy rabbits were used within the scope of the study. The animals were allocated into two groups as Group 1 (control group) and Group 2 (study group). In all subjects, cecal abrasion was formed by laparotomy. In the study group, platelet rich plasma was administered intraabdominally. At the end of the study, the adhesions were evaluated by Nair’s Score.
Results: Total adhesion score in Group 1 was 8, while the mean score was 1. On the other hand, total adhesion score in Group 2 was 12, while the mean score was 1.5. There was no statistical difference between both groups by total adhesion score and mean fibrosis score. However, mean scores for inflammatory cell infiltration and angiogenesis were higher in Group 2 and the differences were statistically significant (p= 0.021).
Conclusion: We were not able to report the positive results of PRP; however, we believe that we shed an important light for future studies which might be conducted using the combination of different methods.
Keywords: Platelet-rich plasma, laparotomy, adhesions
Cite this article as: Turan E, Ayhan B, Kargın S, Doğru O, Uğraş NS. Evaluation of the efficacy of platelet-rich plasma in preventing postoperative intraabdominal adhesions. Turk J Surg 2020; 36 (1): 53-58.
Our study was conducted upon the consent of Necmettin Erbakan University Experimental Research and Practice Center’s Board of Ethics for Experimental Animals and carried out at the same center (2013-022).
This research was not need any informed consent for experimental study.
Concept - B.A., E.T.; Design - O.D., B.A.; Supervision - O.D.; Resource - E.T., B.A., S.K.; Materials - B.A., S.K., S.U.; Data Collection and/or Processing - E.T., B.A., S.K.; Analysis and/or Interpretation - S.K.; Literature Search - E.T.; Writing Manuscript - S.K., O.D.; Critical Reviews - O.D.
All authors declare no conflict of interest and financial relationships.
The authors declared that this study has received no financial support.