EFFECT OF DIFFERENT TYPES OF ENTERAL AND PARENTERAL NUTRITION ON FUNCTIONS AND REGENERATION OF THE LIVER AFTER PARTIAL HEPATECTOMY IN RATS

Abstract

The remnant liver has the capability of regeneration after massive hepatectomy. In order to document and compare the effect of different types of enteral and parenteral feeding forms on liver functions, hepatic regeneration and postoperotive mortality. 70 adult male Wistar-Albino rats (226.59 ± 12.93g) after anesthetized with Diethyl ether (C2H5OC2H5) had 70% hepatic resection. The rats were divided randomly into seven groups; In control group, total hepatectomy was performed, in Group II; 80 kcal/kg/day standart oral feeding (SOF), in Group III; 115 kcal/kg/day ensure plus solution via gastrostomy tube, in Group IV; 110 kcal/kg/day 5% Dextrose, 0.9% NaCI and Hepatamine solution, in Group V; 190 kcal/kg/day 10% Dextrose, 10% Lipid and Hepatamine solution, in group VI; 216 kcal/kg/day 20% Dextrose, 20%Lipid and Hepatamin solution and in Group VII; 260kcal/kg/day 30% Dextrose, 30% Lipid and Hepatamin solution via juguler vein were given. On postoperative day seven, the rest of the liver was removed and blood samples were taken for Albumin, Total protein, and AST and ALT levels and tissue PCNA protein levels were compared. There were no differences between AST and ALT levels among all groups. In group 2 and 3 albumin levels and regeneration of the liver and percentage of hepotocyte nucleus were higher than the other groups (p<0.05). In conclusion, we recommend to return enteral feeding as soon as possible after major hepatic resections.