Study of therapeutic results, lymph node ratio, short-term and long-term complications of lateral lymph node dissection in rectal cancer patients
Habibollah Mahmoodzadeh, Ramesh Omranipour, Anahita Borjian, Mohammad Amin Borjian
Tehran University of Medical Science, Cancer Institute, Tehran, Iran
Abstract
Objective: This study aimed to assess disease free survival, lymph node ratio (LNR) and complication rate among advanced mid to low rectal cancer patients (stage 2-3) who underwent total mesorectal excision (TME) and lateral lymph node dissection (LLND) at the Iran Cancer Institute in 2016-2018.
Material and Methods: The study was carried out on 32 patients treated by curative surgery and lateral lymph node dissection at the Iran Cancer Institute from 2016 March to 2018 March. Chi-square test was used to assess the distribution of dichotomous clinical outcomes by sex. We also used Breslow test in Kaplan-Meier approach to estimate 1-year disease free survival and corresponding 95% confidence intervals (CI).
Results: Of the 279 dissected lymph nodes by TME, 42 nodes (in mesorectal) and of the 232 dissected lymph nodes by LLND, 7 nodes (in iliac, para-iliac and obturator) were positive for metastasis. Higher local recurrence was observed in men (three patients) compared to women (one patient) which was not statistically significant (p= 0.878). We also observed higher 1-year disease free survival rate in women (1-year disease free survival= 93.3%) compared to men (1-year disease free survival= 82.4%), which also was not statistically significant (p= 0.356). 1-year disease free survival rate in patient with negative lymph nodes was 95.5% while respective number in patients with positive lymph nodes was 70% (p= 0.047).
Conclusion: TME with LLND could prolong survival and reduce local recurrence in patients with advanced low rectal cancer. However, large-scale clinical trials are required to evaluate such procedure as a standard in Iran.
Keywords: Rectal neoplasms, lymph node excision, survival, chemoradiotherapy
Cite this article as: Mahmoodzadeh H, Omranipour R, Borjian A, Borjian MA. Study of therapeutic results, lymph node ratio, short-term and long-term complications of lateral lymph node dissection in rectal cancer patients. Turk J Surg 2020; 36 (2): 224-228.
The methodology of the study was reviewed and approved by the medical ethics committee of Tehran University of Medical Science (Approval ID: IR.TUMS.VCR.REC.1397.629-Certificate available on demand).
Written informed consent was obtained from patient who participated in this case.
Externally peer-reviewed.
Concept - H.M.; Design - H.M., A.B.; Supervision - H.M., R.O.; Materials - A.B.; Data Collection and/or Processing - A.B., M.A.B.; Analysis and/or Interpretation – A.B.; Literature Search – M.A.B.; Writing Manuscript – A.B.; Critical Reviews – R.O., H.M.
No conflict of interest was declared by the authors.
The authors declared that this study has received no financial support.
This study was supported by the Cancer Research Center of Iran Cancer Institute. The authors would like to thank all study participants and all of our colleagues at the Iran Cancer Institute who helped us in data collection.