A new approach in bariatric operations: bridged mini gastric by-pass. Is rabbit model suitable for an experimental study?
Aziz Sümer1, Sebahattin Çelik2, Talar Vartanoğlu Aktokmakyan3, Çağhan Pekşen1, Osman Anıl Savaş1, Tutkun Talih4, Tunahan Sancak5, Yağmur Kuşçu5
1Department of General Surgery, İstinye University Faculty of Medicine, Gaziosmanpaşa Medical Park Hospital, İstanbul, Turkey
2Department of General Surgery, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey
3Department of General Surgery, İstanbul Bağcılar Training and Research Hospital, İstanbul, Turkey
4Department of General Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey
5Yüzüncü Yıl University Faculty of Veterinary Medicine, Van, Turkey
Abstract
Objective: Obesity is a global health epidemic with considerable co-morbidities. The increasing demand for bariatric surgery has led to the emergence of new techniques. We modified previously described Mini Gastric By-pass(MGB) technique via leaving a bridge at the most cranial 2 cm of the fundus of the human stomach to the follow-up and treatment of the remnant stomach and duodenum. We would like to entitle this new technique as Bridged MGB and aimed to apply on rabbits as an experimental study.
Material and Methods: The study was performed in the experimental animal laboratory of university after ethical approval was taken from the local ethics committee. Described new technique was applied to 2.1 and 3.2 kg 2 New Zealand rabbits.
Results: As a result of the operations, one of the rabbits died on the day of the operation; the other rabbit was exitus postoperatively on the third day. In autopsies, although no problem was detected at the anastomoses, necrosis was detected in the large curvature of both rabbits.
Conclusion: Rabbit, one of the popular experimental animals, has been shown to be different from the human gastrointestinal system in both arterial and topographic aspects and it has been emphasized that it varies according to the species and even the diet and the climate. We believe that our study failed as a result of these differences and that animals more similar to humans should be used in gastrointestinal experimental studies.
Keywords: Experimental study, mini gastric bypass, rabbit
Cite this article as: Sümer A, Çelik S, Vartanoğlu Aktokmakyan T, Pekşen Ç, Savaş OA, Talih T, et al. A new approach in bariatric operations: bridged mini gastric by-pass. Is rabbit model suitable for an experimental study?. Turk J Surg 2021; 37 (3): 294-298.
The study was approved by the University of Van Yüzüncü Yıl, Regional Committee of Ethics (31008, 03/05/2017).
Externally peer-reviewed.
Concept - A.Z., T.T.; Design - S.Ç., T.S.; Supervision -A.S., T.T., Y.K.; Materials - S.Ç., T.T.; Data Collection and/or Processing - Ç.P., O.A.S.; Analysis and/or Interpretation - T.V.A., Ç.P., T.S.; Literature Search- Ç.P., O.A.S.; Writing Manuscript - T.V.A., T.S.; Critical Reviews - A.S., T.V.A., Y.K.
The authors have no conflicts of interest to declare.
Supported by Van Yuzuncu Yıl University BAP coorrdination unit with referance number TSA-2018-6216.
The study was supported by Yüzüncü Yıl University Scientific Research Projects.