Ramazan Kozan1, İlhan Taşdöven2, Turan Eray Seven2, Selim Aydemir3, Banu Doğan Gün4, Mustafa Cömert2

1Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Türkiye
2Department of General Surgery, Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye
3Division of Gastroenterology, Department of Internal Diseases, Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye
4Department of Medical Pathology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye


Gardner’s syndrome (GS) is a very rare autosomal dominant multisystem disease. Osteomas, skin and soft tissue tumors are present with gastrointestinal polyposis. The polyps have very high malignancy potentials. If prophylactic resection is not performed, colorectal cancer development is inevitable in all patients with GS. Polyposis is usually asymptomatic. Therefore, careful evaluation of extraintestinal findings of the disease is very important for early diagnosis. In this article, diagnosis and treatment of GS are presented in monozygotic twins, which have not been previously described in the literature. The diagnostic process, which started with dental complaints of one case, was carried out in an effective manner and then, prophylactic surgery was performed in twins. This article aimed to make clinicians and dentists attentive for early diagnosis of disease and to review treatment options.

Keywords: Gardner syndrome, twins, intestinal polyposis, osteoma, colorectal neoplasms

Cite this article as: Kozan R, Taşdöven İ, Seven TE, Aydemir S, Doğan Gün B, Cömert M. Gardner’s syndrome: Simultaneous diagnosis and treatment in monozygotic twins. Turk J Surg 2022; 38 (4): 413-417.


Ethics Committee Approval

Externally peer-reviewed.

Author Contributions

Concept – RK, MC; Design – RK, ,İT, MC; Supervision – SA, BDG, MC; Materials - İT, TES, BDG, SA; Data Collection and/or Processing –RK, İT, TES; Analysis and/or Interpretation – RK, SA ,BDG, MC; Literature Search – RK, TES, MC; Writing Manuscript - RK, MC; Critical Reviews – RK, MC.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.