Barış Zülfikaroğlu1, Gökhan Akkurt1, Merve Akın1, Ferruh Kemal İşman2, Ahmet Çınar Yastı1, Mehmet Mahir Özmen3

1Clinic of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Türkiye
2Clinic of Clinical Chemistry, Göztepe Training and Research Hospital, İstanbul, Türkiye
3Department of Surgery, İstinye University Faculty of Medicine, İstanbul, Türkiye


Objective: One of the most prevalent abdominal crises is acute appendicitis (AA). Clinical diagnosis, even for skilled surgeons, is frequently challenging, as indicated by the high proportion of negative investigations. The purpose of this study was to see if serum TWEAK levels might be used to diagnose acute appendicitis.

Material and Methods: Between June 2017 and May 2019, all patients who had surgery with the original diagnosis of AA were included in the study. TWEAK, WBC, CRP, and bilirubin levels were compared.

Results: The levels of WBC, CRP, and bilirubin were compared to pathology. All three blood indicators increased significantly in AA patients. However, no statistically significant difference in the levels of all three blood indicators was seen between individuals with simple AA and those with severe AA. TWEAK plasma concentrations were considerably greater in patients with severe AA than in the healthy control and NAA groups. TWEAK levels were significantly greater in individuals with severe AA compared to patients with simple AA.

Conclusion: Serum TWEAK levels that are elevated may be used to diagnose acute appendicitis as well as prognostic indicators for the severity of appendicitis.

Keywords: Acute appendicitis, inflammation, marker, severity, tumor necrosis factor-like weak inducer of apoptosis

Cite this article as: Zülfikaroğlu B, Akkurt G, Akın M, İşman FK, Yastı AÇ, Özmen MM. Role of serum levels of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in predicting severity of acute appendicitis. Turk J Surg 2023; 39 (2): 121-127.


Ethics Committee Approval

The ethical approval for this study was obtained from Göztepe Training and Research Hospital, İstanbul Medeniyet University Institutional Ethics Committee (Date: 15.08.2018, Decision No: 2018/315).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - BZ, FKI; Design - BZ, ACY, MMO; Supervision - MMO; Materials - GA, MA; Data Collection and/or Processing - GA, MA; Analysis and/or Interpretation - BZ, GA, MA; Literature Search - MA, GA; Writing Manuscript - BZ, ACY; Critical Reviews - ACY, FKI, MMO.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.