Liver biopsy in patients with gall stone disease and concomitant non-alcoholic fatty liver disease undergoing cholecystectomy: A prospective observational study
Aaron John1
, Utpal Anand2, Tarun Kumar3, Rohith Kodali2, Kunal Parasar2, Ramesh Kumar4, Rajeev Priyadarshi5, Basant Singh2, Kislay Kant2
1Clinic of Gastrointestinal, HPB, Multi Organ Transplant Surgery, Rajagiri Hospital, Kochi, India
2Department of Surgical Gastroenterology, All India Institute of Medical Sciences, Patna, India
3Department of Pathology, All India Institute of Medical Sciences, Patna, India
4Department of Medical Gastroenterology, All India Institute of Medical Sciences, Patna, India
5Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, India
Abstract
Objective: Gallstone disease (GSD) and non-alcoholic fatty liver disease (NAFLD) share common risk factors. NAFLD can progress to non-alcoholic steatohepatitis (NASH), which may lead to severe liver conditions. This study aimed to assess the prevalence of NASH and associated factors in patients with GSD and fatty liver undergoing cholecystectomy.
Material and Methods: This prospective observational study was conducted from March 2021 to June 2023 and included 134 patients diagnosed with GSD and fatty liver based on preoperative ultrasound. Core liver biopsies were obtained during cholecystectomy. Preoperatively, clinical, anthropometric, demographic, biochemical variables, and FibroScan parameters were recorded.
Results: NASH was found in 21 (15.67%) patients, while 50 (37.31%) patients had probable NASH, and 63 (47.01%) had non-NASH scores. Metabolic syndrome was present in 63.6% of the patients. Univariate analysis revealed significant differences in AST and ALT values between the NASH and nonNASH groups. In multivariate analysis, AST was statistically significant (p= 0.041). Mean controlled attenuation parameter in patients with non-NASH was 219.40 ± 60.44 dB/m, and in patients with NASH, it was 265.48 ± 63.47 dB/m (p= 0.006). Fibrosis was present in 33 of the 82 slides examined, with 17 patients having grade 2 and two patients with grade 3 fibrosis.
Conclusion: The high prevalence of NASH among GSD patients highlights a significant public health issue, prompting consideration for liver biopsy in individuals with NAFLD and GSD undergoing laparoscopic cholecystectomy.
Keywords: Gallstone disease, NAFLD, NASH, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis
Cite this article as: John A, Anand U, Kumar T, Kodali R, Parasar K, Kumar R, et al. Liver biopsy in patients with gall stone disease and concomitant non-alcoholic fatty liver disease undergoing cholecystectomy: A prospective observational study. Turk J Surg 2024; 40 (3): 190-196.
This study was obtained from All India Institute of Medical Sciences Institutional Ethics Committee (Decision no: AIIMS/ Pat/IEC/PGTh/Jan20/09 Date: 01.03.2021).
Externally peer-reviewed.
Concept - UA, RK, RP; Design - UA; Supervision - UA, RK, RP; Data Collection and/or Processing - AJ, RK, KP; Analysis and/or Interpretation - AJ, BS, KK; Literature Search - AJ, BS, KK; Writing Manuscript - AJ, BS, KK; Critical Reviews - AJ, RK, KP, RK, RP, BS, KK.
The authors have no conflicts of interest to declare.
The authors declared that this study has received no financial support.