THE EFFECTS OF TRIMETAZIDINE ON BACTERIAL TRANSLOCATION AND LIVER CELL INJURY DEVELOPED DUE TO OBSTRUCTIVE JAUNDICE

Abstract

Bacterial translocation developing following obstructive jaundice is among the most important causes of sepsis. Damage develops in liver cells following jaundice and this initiates various physiopathological events. In this study, the effects of trimetazidine on bacterial translocation and the liver cell damage developing due to obstructive jaundice in rats were investigated. Adult male Wistar Albino rats were placed in three groups: Group 1 (n=10) controls had sham operation, Group II (n=10) had ligation and division of common bile duct. Group III (n=10) was given a single 3 mg/kg dose of trimetazidine, intraperitoneally, after 24 hours of the ligation and the division of common bile duct; and the same doses were repeated daily for seven days. Throughout the study rats were fed on standart rat chow. At the end of the one week period AST and ALT values were significantly high in Group II compared with the other two groups (p<0.01). Bacterial translocation in Group III was less than Group II and this was statistically significant (p<0.05). In histopathological examinations of ileum Grade 1 changes were observed in the rats in Groups 1 and III. Grade 2 changes were observed in two rats in Group II. In this study it has been concluded that trimetazidine may reduce the jaundice related to liver cell damage and prevent bacterial translocation.