PRE AND POSTOPERATIVE SERUM LEVELS OF TUMOR MARKERS IN GASTROINTESTINAL SYSTEM TUMORS
OSMAN NURİ DİLEK1, METİN AYDIN1, OSMAN GÜLER1, M KÜRŞAD TÜRKDOĞAN2, M RAMAZAN ŞEKEROĞLU3, MEHMET TARAKÇIOĞLU3, ERSİN ÖZGÖREN1
1Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Genel Cerrahi ABD, VAN
2Yüzüncü Yıl Üniversitesi Tıp Fakültesi, İç Hastalıkları ABD, VAN
3Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Biyokimya ABD, VAN
To determine the effect of surgery on serum tumor marker level serum ferritin, AFP, CEA, Ca-19.9, and Ca-125 levels were measured by immunoradiometric assay in 19 patients. The patients were operated for gastrointestinal malignities (8 gastric, 5 colorectal, 6 esophageal tumor). Serum tumor marker levels were measured preoperative and postoperative 7thday. Following the operation, serum ferritin and Ca-125 levels elevated above the cut-off levels in most of the patients, (95% Confidence Interval-CI, preop; 9.2-51.2 and 16.3-61.6 postop; 28.9-75.6 and 66.9-99.7) but CEA and Ca-19.9 levels decreased in most of the patients (Cl preop; 33.5-79.8 and 12,6-56.6, postop; 1,3-33. 1 and 0-17,7). AF:P levels did not change in all patients (Cl, preop and postop 0-17.7). We think that, increased serum ferritin levels may be a result of release of ferritin from damaged liver cell due to anaesthetics agents and also increased Ca-125 levels may be explained as a result of damaged tissue due to anaesthetics agents and drugs. Decreasing of CEA levels may be explained as a result of debulking.
Keywords: TUMOR MARKER, GASTROINTESTINAL TUMOR, CEA, AFP, FERRITIN, CA-125, CA-19.9