THE INHIBITORY EFFECT OF DISULFIRAM ON EXPERIMENTAL COLON CARCINOGENESIS
GÜRSEL SOYBİR1, MUHAMMED AKAN1, AYSENUR AKYILDIZ İĞDEM2, ALİ ÖZŞEKER1, FEZA EKİZ1, YALÇIN AKER3
1S.B. Taksim Hastanesi, 1. Cerrahi Servisi, İSTANBUL
2S.B. Taksim Hastanesi, Patoloji Servisi, İSTANBUL
3Celal Bayar Üniversitesi, Cerrahi Anabilim Dalı, MANİSA
Abstract
The chemopreventive effect of disulfiram (DSF) on experimental colon carcinogenesis has been investigated in this study.
65maleCD-1 mice weighing 30-35 gr were separated into three groups, Colon carcinogenesis was induced by daily subcutaneous dimethylhydrazin (DMH) injections. DSF was given daily 25 mg/Kg doses in drinking water, DSF started five days before DMH injections and continued during the experiment. Mice were sacrificed at 31 st week of the experiment and histopathologic analysis were made in colon and other intraabdominal organs.
There were significant differences in incidence, multiplicity and size of tumours between the groups. It has been understood that, DSF in drinking water, has an inhibitory effect on experimental complete colon carcinogenesis.
Keywords: COLON CARCINOGENESIS, MOUSE, DISULFIRAM