THE PROTECTIVE EFFECT OF NITRIC OXIDE IN ETHANOL-INDUCED GASTRIC MUCOSAL DAMAGE
AKIN ÖZDEN1, UĞUR SUNGURTEKİN1, AYŞE BİLGİHAN2, REŞATÖZERCAN3, MEHMET NEŞŞAR1, NURTEN TÜRKÖZKAN3
1Pamukkale Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, DENİZLİ
2Gazi Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, ANKARA
3Fırat Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, ELAZIĞ
In this study, the effect of nitric oxide (NO) was investigated on ethanol induced gastric mucosal lesions in rats. A total of 36 rats were allocated to six groups: These were 1. Control group, 2. Control + NwNitro-L-arginine (NwNA), 3. NwNA + ethanol, 4. ethanol, 5. L-arginine + ethanol and 6. NwNA + L-arginine + ethanol groups. It has been observed that administration of L-arginine exogenously, which is the precursor of NO besides ethanol in group 5, significantly reduced histopathologic damage and malonyledialdehyde leveis in tissue than those of groups 3 and 4. MDA levels in group 4 was lower than group 3 which NO was inhibited by administrating NwNA. These results show the preventive role of NO in ethanol-induced gastric mucosal lesions.
Keywords: GASTRIC MUCOSAL INJURY, NITRIC OXIDE