THE EFFECT OF INTRAPORTAL PROSTACYCLIN INFUSION ON HEPATIC GLYCOGEN CONTENT IN LIVER TRANSPLANTATION
CUMHUR YEĞEN1, A ÖZDEMİR AKTAN1, ÖMER GÜNAL2, İLHAN ONARAN2, SERAP ARBAK3, RIFAT YALIN1
1Marmara Üniversitesi Hastanesi, Genel Cerrahi Anabilim Dalı, İSTANBUL
2Marmara Üniversitesi Hastanesi, Biyokimya Anabilim Dalı, İSTANBUL
3Marmara Üniversitesi Hastanesi, Histoloji Anabilim Dalı, İSTANBUL
It was demonstrated that glycogen stores could be rapidly repleted in pig by intraportal infusions of glucose and prostacydin during donor operation. Livers from nutritionalty repleted animals are less susceptible to injury originating from cold ischemia and in this may also improve the posttransplant initial function. Prostacyclins have long been known as a cytoprotector and they can regulate the hepatic microsirculation. The aim of this study is to determine whether the infusion of prostacylin and glucose have synergistic action on hepatic glycogen content. Two groups of pig were replenished nutritionally either glucose (group 1) or glucose + prostacycline (group 2) by portal route during donor operation. Hepatic glycogen content was found to be significantly increased in group 2 when compared with group 1, and values were maintained higher during the operative procedure.
It is concluded that glucose and prostacylin infusions may be useful for the glycogenisation of donor liver ad may improve the outcome of transplantation.
Keywords: LIVER TRANSPLANTATION, GLICOGEN, PROSTACYCLIN