HLA ANTIGENS IN GASTROINTESTINAL CARCINOMAS
TURGUT İPEK1, BAYRAM KAYABAŞI1, ERKAN YILMAZ2, HAKAN KÖKSAL1, ARİF KUBAT3, BERAT APAYDIN1
1İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İSTANBUL
2Kan Merkezi Doku Tipi Laboratuarı, İSTANBUL
3İstanbul Üniversitesi Bilgisayar Bilimleri, Uygulama ve Araştırma Merkezi, İSTANBUL
Abstract
The associations of human diseases and particular HLA types are known (Behçet's disease B5, BR7 Reiter's syndrome and Ankylosan Spondilitis etc). We tried to show the relationship between gastrointestinal adenocarcinomas and HLA system in Turkish population. We investigated HLA DR and ABC antigens on adenocarcinoma cells of GI tract and normal volunteer (22 patients and 160 normals), We found that GI tract carcinomas were associated with HLA DR 11 (p<0.02) and HLA B67 (p<0.01).
Keywords: HISTOCOMPATIBILITY ANTIGENS (HLA), TUMORS