AHMET ÇÖKER1, IŞIL ÇÖKER2, MURAT KAPKAÇ1, MUSTAFA KORKUT1, ADEM GÜLER1, ÖZDEMİR YARARBAŞ1

1Ege Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İZMİR
2SSK Tepecik Hastanesi Biyokimya Laboratuarı, İZMİR

Abstract

In this study, in vitro adhesion and chemotaxis of leucocytes have been searched in rabbits. Animals were divided in to three groups as control, sepsis and sepsis plus omeprazol. Chemotaxis was inhibited in the last group significantly but differences between adhesion percentages were nonsignificant. As a result H/K ATS'ase enzyme system has not only been seen in gastric parietal cells, but also in neutrophiles, and omeprazol might effect neutrophile leucocyte functions. That observation needs to be supported by randomised and double blind clinical trials.

Keywords: OMEPRAZOL, ULCER, PEPTIC ULCER, CHEMOTACTIC FACTORS, LYMPHOCYTE SUBSETS