Prognostic factors of stage III-B breast cancer after downstaging and modified radical mastectomy
Burak Kavlakoğlu, Seçkin Akküçük, Süleyman Oral
S.B. Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi 3. Cerrahi Kliniği, ANKARA
Purpose:The purpose of this study was to determine the prognostic information from mastectomy and axillary node dissection in patients with stage III-B breast cancer after down staging.
Materials and methods: Mastectomy and axillary dissection was performed for 97 patients with stage III-B breast cancer after downstaging. Estrogen receptor status, histologic type, median number of axillary lymph nodes, median number of positive axillary lymph nodes, positive lymph nodes / total lymph nodes ratio were analysed. Overall survival and disease free survival were determined for five years. Survival was calculated using the Cox regresion method.
Results: Median number of total axillary lymph nodes was 20,2; median number of metastatic axillary lymph nodes was 8,9; positive lymph nodes / total lymph nodes ratio was 0,44. Among the 80 patients (except 17 unknown receptor status) 35%were found to have estrogen receptor positive and 86 cases (%88,7) were invasive ductal cancer on pathologic examination of the axillary contents. Five year overall survival and disease free survival rates were %38,7 and %28 respectively.
Conclusion: Estrogen receptor status, ratio of positive axillary lymph nodes and inflammatory breast cancer effect 5 year survival rates after total mastectomy and axillary dissection.
Keywords: Locally advanced (stage IIIB) breast cancer, axillary lymph node metastasis.