SERUM D(-)-LACTATE LEVELS IN EXPERIMENTAL INTESTINAL ISCHEMIA
S SELÇUK ATAMANALP1, AHMET A BALIK1, M İLHAN YILDIRGAN1, MAHMUT BAŞOĞLU1, AHMET KIZILTUNÇ2, ZEKAT ERMAN3
1Atatürk Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, ERZURUM
2Atatürk Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, ERZURUM
3Atatürk Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, ERZURUM
In this study we investigated serum D(-)-lactate levels as a marker of acute intestinal ischemia in an experimental model. Forty rabbits were divided into five groups each containing 8 animals. The five groups included: Sham laparotomy group (control), and superior mesenteric artery ligation groups (30, 60, 120 and 180 minutes, respectively). We found statistically significant elevations in serum D(-)-lactate concentrations in SMA ligation groups compared to control group. Additionally these elevations were in positive correlation with prolonged ischemia times. As a result we have concluded that serum D(-)-lactate concentration may be a useful marker of mesenteric ischemia.
Keywords: INTESTINAL ISCHEMIA, D(-)-LACTATE