THE EFFECT OF MINIMAL DOSE OF INTRAARTERIAL STREPTOKINASE IN EXPERIMENTAL SUPERIOR MESENTERIC ARTERY THROMBOSIS
GÜRKAN YETKİN1, BURÇAK KABAOĞLU1, MEHMET MİHMANLI1, ADNAN İŞGÖR1, GÜLEN DOĞUSOY2
1Şişli Etfal Hastanesi 2. Genel Cerrahi Kliniği, İSTANBUL
2İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İSTANBUL
This study was aimed to assess the effect of intraarterial Streptokinase in reversing the effect of SMA thrombosis induced experimentally in Wistar-Albino rats.
SMA thrombosis was induced surgically in 14 Wistar-Albino rats, then these were separated in two groups consisting of 7 rats each. The control group was perfused with saline through to SMA and the study group with streptokinase. After 24 hours, the small intestine segments affected were evaluated for necrosis histopathologically. In the first group, necrosis was seen in all 7 specimens (100%) (2 light, 1 moderate, 4 heavy necrosis). In the second group, where minimale dose streptokinase was used instead of saline, necrosis was observed in only 4 of 7 specimens (57.1%) (2 light and 2 heavy necrosis).
In conclusion, minimal dose streptokinase, given intraarterially in SMA thrombosis induced experimentally in Wistar-Albino rats, was found to be effective in reversing the effects of thrombosis as assessed by the degree of necrosis.
Keywords: STREPTOKINASE, ISCHEMIA, NECROSIS