THE PREVENTIVE EFFECTS OF OXYGEN RADICAL SCAVENGERS IN EXPERIMENTAL MAMMARY CARCINOMA
GÜRSEL SOYBİR1, ORHAN YALÇIN1, HÜLYA KOYUNCU2, YALÇIN AKER1, CEMALETTİN TOPUZLU2, HAKKI KÖSE1, FERDA KÖKSOY1, ÖNER DOĞAN3, FERHUNDE DİZDAROĞLU3, TUNCAY ALTUĞ4, AHMET DİRİCAN5
1S.B. Taksim Hastanesi 1. Cerrahi Kliniği, İSTANBUL
2İstanbul Üniversitesi, Onkoloji Enstitüsü, İSTANBUL
3İstanbul Üniversitesi, Tıp Fakültesi, Patoloji ABD, İSTANBUL
4İstanbul Üniversitesi, Deneysel Tıp Araştırma Merkezi, İSTANBUL
5Cerrahpaşa Tıp Fakültesi Tıbbi İstatistik ABD, İSTANBUL
Abstract
This study was carried out to investigate the effects of free oxygen radical scavengers in 7, 12-Dimethyl-benz-(a)anthrasen induced mammary carcinoma. Free oxygen radical production, thus carcinogenesis was tried to be blocked by various agents such as iron chelator and radical scavenger agent Mangan-Desferrioxamine and calcium antagonist and radical scavenger agent Verapamil, and the results were compared.
The results revealed that while Mangan-Desferrioxamine group showed significant differences both in tumor incidence (p<0.02) and survival without tumor (p<0.05), Verapamil group showed a significant difference only in tumor incidence (p<0.04) when compared with other groups.
Prevention groups (Mangan-Desferrioxamine and Verapamil) showed significant differences when compared with the non-prevention group in flow cytometric studies (p<0.004 for proliferation indexes) and tumor weights (p<0.02 in 20th week).
In conclusion; Mangan-Desferrioxamine and Verapamil have offered prevention in experimental complete mammary carcinogenesis. These agents have caused slower and less agressive tumor growth in rats though they couldn't achieve a complete prevention.
Keywords: EXPERIMENTAL RAT MAMMARY CANCER, FREE OXYGEN RADICAL MANGAN-DESFERRIOXAMINE, VERAPAMIL