EFFECT OF LOW MOLECULAR WEIGHT HEPARIN IN THROMBOSIS AFTER VENOUS CATHETERIZATION
HİLMİ KOCAOĞLU1, CÜNEYT KÖKSOY2, SERPİL DİZYAK SAK3, M ALİ YERDEL2, Recep ÇETİN1, A RIZA ARAT1
1Ankara Üniversitesi Tıp Fakültesi, Cerrahi Onkoloji Bilim Dalı, ANKARA
2Ankara Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, ANKARA
3Ankara Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, ANKARA
Abstract
In this study, the efficacy of low-molecular weight heparin (LMWH) in the prophylaxis of catheter-related venous thrombosis is investigated in a prospective fashion by using a rabbit model.
A polyurethane catheter was inserted into the jugular vein of all the rabbits both in study group and the control group. In this study group, there were 24 rabbits and everyday 150 anti-Xa ICU/kg/day Fraxiparine was injected subcutaneously. No treatment was done to the control group which consisted of 24 rabbits. On the 2nd, 7th and 14th days, the catheters were withdrawn and histopathologically examined with special reference to the presence of venous thrombosis.
Postoperative autopsies at day 2 after sacrifice revealed no thrombosis in 8 animals receiving Fraxiparine and 6 of 8 animals (75%) in the control group were found to have thrombosis (p<0.05)
Autopsies at day 7 after sacrifice revealed that 2 of 8 animals in the Fraxiparine group (25%) and all animals (n:8) in the control group (100%) developed thrombosis (p<0.05).
Autopsies at day 14 after sacrifice revealed that 2 of 8 animals in the Fraxiparine group (25%) and all animals in the control group (100%) developed venous thrombosis (p<0.05).
According to these findings, Fraxiparine significantly lowered the incidence of catheter related venous thrombosis (p<0.05).
We suggest that daily single-dose Fraxiparine injection maybe an effective way of preventing catheter-related venous thrombosis.
Keywords: VEIN CATHETERIZATION, VENOUS THROMBOSIS, LOW MOLECULAR WEIGHT HEPARIN