THE SYNERGISTIC EFFECTS OF VITAMIN E ON THE PREVENTION OF POSTOPERATIVE ADHESIONS
HALUK TOKMAK1, HASAN B TİBET1, MÜJDAT BALKANLI2, KÖKSAL ÖNER2, RACİ AYDIN1
1Dr. Muhittin Ülker Acil Yardım ve Travmatoloji Hastanesi, Genel Cerrahi Kliniği, ANKARA
2Gülhane Askeri Tıp Akademisi ve Askeri Tıp Fakültesi, Genel Cerrahi Kliniği, ANKARA
Abstract
The synergistic effects of vitamin E on 32% dextran 70 and aprotinin for the prevention of postoperative intraabdominal adhesions were evaluated. A total of 58 Sprague-Dawley rats were included in control, 32% dextran 70, aprotinin, vitamin E, vitamin £+32% dextran 70, vitamin E+aprotinin groups. Procedure was performed by making three serosal incisions and having a silk suture on the cecum. There were significant adhesions; 80% in the control, 70% in the 32% dextran 70, 60% in the aprotinin, 40% in the vitamin E, 25% in the vitamin E+32% dextran 70 groups. There was no significant adhesions in the vitamin E+aprotinin group, and this was significantly important when it was compared with the control, 32% dextran 70 and aprotinin groups (p<0.05).
Keywords: ADHESION, 32% DEXTRAN 70, APROTININ, VITAMIN