CUSHING SYNDROME
ALP GÜRKAN1, NEŞET KÖKSAL2, AHMET ÇÖKER3, YAMAN TOKAT3, HASAN KAPLAN3, ÖZDEMİR YARARBAŞ3
1SSK Tepecik Hastanesi, 3. Cerrahi Kliniği, İZMİR
2Kartal Eğitim ve Araştırma Hastanesi, 1. Genel Cerrahi Kliniği, İSTANBUL
3Ege Üniversitesi Tıp Fakültesi Hastanesi, Genel Cerrahi Anabilim Dalı, İZMİR
Abstract
Cushing syndrome is a rare entity which is caused by adrenocortical hyperfunction. Its incidence is six in a million population. During 1977-92 23 patients were hospitalized in E.U.T.F. General Surgery Department retrospectivety. 22 of these patients were operated. A patient who had metastasis in the lungs was not operated. In the etiology 11 of the patients had carsinoma of the adrenal cortex, 7 of them showed bilateral diffuse hyperplasia, 4 had nodular hyperplasia, 1 of them had adrenal adenoma, and one had ectopic adrenal gland.
In 11 of the cases unilateral total adrenalectomy, in 7 of them bilateral total adrenalectomy, was performed. 3 of them had total on one side, and subtotal adrenalectomy done on the other side. One of the cases was decided to be inoperable, so only biopsis was performed.
Among the 22 operated patients, in the postoperatfve period, only one died because of disseminated intravascular coagulopathy. Only 8 of the other 21 patients were been able to be followed-up. Among these patients, one of them had metastasis in the lungs after 4 years. After 3 years another one showed iatrogenic Cushing Syndrome. 3 of them died after 2 months, 4 and 6 years respectively. 3 patients still have no complaints.