EFFECTS OF PENTOXIFYLLIN IN EXPERIMENTAL ISCHEMIC ACUTE RENAL FAILURE
ENVER İHTİYAR1, ERGİN AÇIKALIN2, SERDAR ERKASAP1, ERSİN ATEŞ1, TARIK ÇAĞA1, HALUK KİPER1
1Anadolu Üniversitesi Tıp Fakültesi, Genel Cerrahi Kliniği, ESKİŞEHİR
2Anadolu Üniversitesi Tıp Fakültesi, Histoloji-Embriyoloji Anabilim Dalı, ESKİŞEHİR
Abstract
In this experimental study, the effects ol Pentoxifylline ischemic acute renal failure was investigated. This agent is a prostocyline stimulator on the vascular tree and an adenosine reseptor antagonist as well. For the purpose, in the control group (n=10) rate were undergone right side nephrectomy, followed by renal ischemia at the controlateral side for 60 minutes. in the study group (n=22) the same procedure was applîed, however after 60 minutes ischemia, 45 mg/kg Pentoxifylline was administered intraperitonealy, just after the clamp at the renal pedicle had been removed. Serum Na, K, BUN and Cre tevels were measured 48 hours later and ischemic kidneys were removed for histopathological studies. The results has shown that the biochemical measurements were not significant statistically in the study and control groups. However, histopathological examinations revealed a significant reduction at congestion. In the study group which was given pentoxifylline, pentoxifylline was shown to restorate renal blood flow most probably, not only reducing blood viscosity, but also improving microcirculation and stimulatory effect on the prostacycline syntesis.