HEPATIC HISTOPATHOLOGICAL CHANGES AND LIVER FUNCTION TESTS IN EXPERIMENTAL HYPERTHYROIDIC GUINEA PIGS

Abstract

In this study, we aimed to investigate the effect of experimental hyperthyroidism on liver in guinea pigs. 24 guinea pigs of 640 + 110g weight were used. The guinea pigs were divided into three groups: Control group (group A), 10 mM NaOH group (group B), and L-triiodothyronine group (group C). Blood samples were drawn before and after the experiment. Alanin amino transferase (ALT), alkaline phosphatase (AP), aspartat amino transferase (AST), gama glutamil transpeptidase (GGT) were determined in blood samples. Following the 16th. day, guinea pigs were sacrificed, liver biopsies were taken and were examined under light microscopy.

In group C in which hyperthyroidisim was formed, no significant difference between ALT and AST values before and after experiment was detected (p>0.05). The AP and GGT values in group C were significantly higher than other groups (p<0.05) (Tablo 2).

In histopathologic examination of liver in L-triiodothyronine group (group C), normal findings were observed in 20%. Local necrosis, portal inflammation, PMNL infiltration and hyperemia were observed in 80% (Table 3).

In other two groups, no significant histopathological difference was observed.

We found the increase in liver function tests and histopathological changes in guinea pigs in which hyperthyroidism was formed.

As a result we believe that in suspicious cases where liver illness is investigated, the investigation of hyperthyroidism maybe beneficial.