EFFECT OF INCREASING INTRAABDOMINAL PRESSURE ON HEPATIC AND RENAL FUNCTION AND THEIR STRUCTURE

Abstract

The possible effect of the elevation of Intraabdominal pressure (IAP) on hepatic and renal function and their histologic structure was researched in this experimental study. The serum levels of BUN, creatinine, SGOT, SGPT and alkaline phosphatase were increased stepmise to 20, 40 and 60 mmHg on a hourly set. Urinary output and creatinine clearence were also assessed accordingly. The histopathological changes in liver and kidney were periodically investigated. The mean serum levels of BUN, creatinine, SGOT, SGPT and alkaline phosphatase showed steady rise as IAP increased while urinary output and clearence values declined. Histopathological changes were venous stasis and ischemia in liver, and acute tubular necrosis in kidney. The intensity of these changes were found in close correlation with the grade of IAP elevation. 20 mmHg was the threshold value of IAP that commenced detrimental changes in organ function and structure. As projected to the clinical cases, the results of this study implied that the abdominal distension, especially the ones with moderate to high in grade, should be decompressed as earty as possible.