THE EFFECT OF DONOR-SPECIFIC BLOOD TRANSFUSIONS ON GRAFT SURVIVAL
NİHAT YAVUZ1, HASAN KALAFAT1, METİN ERTEM1, AHMET ALPONAT1, DİLEK GOGAS4, AHMET DİRİCAN2, GÜLŞEN ÖZBAY3
1İ.Ü. Cerrahpaşa Tıp Fakültesi, Genel Cerrahi A.B.D., İSTANBUL
2İ.Ü. Cerrahpaşa Tıp Fakültesi, Bioistatistik Bilim Dalı, İSTANBUL
3İ.Ü. Cerrahpaşa Tıp Fakültesi, Patoloji ABD, İSTANBUL
4Marmara Üniversitesi Tıp Fakültesi, İç Hastalıkları ABD, İSTANBUL
Abstract
In this experimental study, the effect of pretransplant donor-specific blood transfusions on graft survival has been investigated. Wistar albino rats were used as donors and Sprague Dowley rats as recipients. 5 study groups were established in each of which were a total of 12 animals consisting of 6 donors and 6 recipients. Transplantations have been realized by administering pretransplant DST three times to the 1st group, twice to the 2nd group and once to the 3rd group, Cyclosporin A (CyA. 10/mg/Kg/İm) was administered posttransplant to the 4 group in addition to pretransplant DST which was administered once. On the other hand, only transplantation was applied to the control group.
Analizing the results; it has been observed that pretransplant DST had a positive influence on the graft survival and this influence was the greatest on the 1 group which was given the transfusion three times (mean graft survival time: 11.83 ( 1.57 days).
Keywords: DONOR-SPECIFIC BLOOD TRANSFUSIONS (DST), REJECTION, GRAFT SURVIVAL, CYCLOSPORIN A (CYA)