EXPERIMENTAL COLITIS
HAKKI KÖSE1, FERDA KÖKSOY1, ORHAN YALÇIN1, GÜRSEL SOYBİR1, TÜRKER BULUT2, TÜLAY BAŞAK3
1Taksim Hastanesi 1.Cerrahi Kliniği, İSTANBUL
2İ.Ü. İstanbul Tıp Fakültesi Genel Cerrahi ABD, İSTANBUL
3Şişli Etfal Hastanesi Patoloji Kliniği, İSTANBUL
Abstract
Protective effect of Desferrioxamine, Disulfiram, Superoxide Dismutase (SOD) and Catalase (CAT) on experimental colitis induced by 4% acetic acid has been investigated in this experimental study. 30 Wistar Albino rats have been divided in to 5 groups. No drug was given to the control group. The second group was given Desferrioxamine, third group disulfiram, fourth group SOD, fifth group SOD+CAT.
Analysis of the results revealed significant cytoprotection by desferrioxamine which as a iron chelating agent, anda by Disutfiram, while SOD and Catalase has been found to be ineffective.
Keywords: EXPERIMENTAL COLITIS, DESFERRIOXAMINE, DISULFIRAM, SUPEROXIDE DISMUTASE, CATALASE