THE PREVENTIVE EFFECT OF CARBOXYMETHYL CELLULOSE (CMC) ON THE INTRAPERITONEAL ADHESIONS IN RATS
İRFAN COŞKUN, MEHMET EMİN İRFANOĞLU, AHMET RAHMİ HATİPOĞLU
Trakya Üniversitesi Tıp Fakültesi, Genel Cerrahi A.B.D./EDİRNE
Abstract
The effect of Carboxymethyl Cellulose(CMC) to prevent the post-operatively developing adhesions is Investigated. Terminal ileum and cecal brushing is carried out via laparotomy on three study groups each consisting of 20 rats. Then 5ml. of 10% Dextran 40 and 5ml. of 1% CMC is instilated intraperitoneally to the two therapy groups consequently, while 5ml. of isotonic NaCl is instilated to the control group. When checked on the post-operative 10th day, the adhesions in the therapy groups are found significantly lower than the control rats (p<0.01). On the other hand, CMC receiving rats showed significantly less adhesions than those treated with Dextran 40 (p <0.05).