THE EFFECTS OF IMMUNOLOGICAL CHANGES ON WOUND HEALING SUCCEEDING SKIN TRANSPLANTATION IN RATS
HAMDİ KOÇER1, YUSUF ERÇİN SÖNMEZ1, ESMA SÜRMEN2, NEJAT SAVCI3, İLGİN ÖZDEN1, ORHAN ARIOĞUL1
1İstanbul Tıp Fakültesi Genel Cerrahi A.B.D. /İSTANBUL
2İstanbul Tıp Fakültesi Biyokimya A.B.D. /İSTANBUL
3İstanbul Üniversitesi Onkoloji Enstitüsü, Patoloji A.B.D., İSTANBUL
Abstract
Following skin transplantation and administration of two different immunosupressive drugs, the effects of immunological changes on abdominal wound healing is studied in rats. Tissue hydroxyprolin values are found to be lower in three groups used cylclosporin, metilprednisolon and no immunosupressive drug (rejection group) than the control group. To achieve a regular wound healing sequence, the immunological status ought not to be disturbed either to stimulation or suppression. Bearing in mind the modulatory effects of immunosupressive drugs on collagen synthesis, the prominence of using the proper immunosuppressive protocol with premium dosage will be well understood.