THE ROLE OF GALLSTONE COMPOSITION ON THE RATE OF DISSOLUTION OF GALLBLADDER STONES BY MTBE
ZAFER MALAZGİRT1, NECATİ ÖZEN1, ERCÜMENT ERSÖZLÜ1, KAYHAN ÖZKAN1, AHMET KORKMAZ2, İSMAİL GÜMRÜKÇÜOĞLU3
1Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Genel Cerrahi A.B.D./ SAMSUN
2Ondokuz Mayıs Üniversitesi, Ziraat Fakültesi / SAMSUN
3Ondokuz Mayıs Üniversitesi, Fen Fakültesi / SAMSUN
Abstract
The major organ/c and inorganic constituents of gallstones and their rate of dissolution by MTBE was separately determined in 40 pairs of gallbladder stones. The stones were categorized into four groups according to how rapidly they dissolved by MTBE., The cholesterol and calcium content together with the type of calcification were found as the three relevant factors influencing the rate of dissolution. The cholesterol and calcium ratios of rapidly dissolving stones were 1.7% and 0.8% while respective values of 0.1% and 14.9% (p>0.05) were obtained for undissolving stones. All of the stones other than cholesterol showed a pattern of dissolution which was characterized by an initial lag phase that followed by a phase of rapid dissolution.