VERAMPIL AND PENTOXYFLLINE IN PREVENTION OF INTRAPERITONEAL ADHESIONS
GÜRKAN ERSOY, ZAFER UTKAN, ŞEHSUVAR GÖKGÖZ, NURİ GÖNÜLLÜ, MUSTAFA DÜLGER
Cumhuriyet Üniversitesi Tıp Fakültesi Uygulama ve Araştırma Hastanesi Genel Cerrahi ABD/SİVAS
Adhesions that are seen either in early or late term of postoperative periods still create great problems even with a great number of agents and procedures used till today continue to increase morbidity and mortality rate. In this study, we investigated if parenteral Verapamil or Pentoxyftline application has inhibitory effects on peritoneal adhesions developing in the postoperative early period.
With this respect, 21 guinea pigs were divided into Control, Verapamil and Pentoxyflline groups. For each pig, a defect in standard manner was formed on the peritoneal surface following laparatomy. While no supplementary treatment has been applied to the control group, 200 µg/kg/day Verapamil for Verapamil group and 2.5 µg/kg/day pentoxifylline for pentoxifylline groups with two dosages per day and for a four day period was applied subcutaneously during the postoperative period. Later the localization and the frequency of adhesions were evaluated with the presence of two neutral supervisors. As a result, it was perceived that there is no statistical significant difference in respect of intra abdominal adhesions protecting between the Verapamil-Control and Pentoxifylline-Control groups during postoperative early periods (p>0.05).
Keywords: ADHESIONS, PERITONEUM, VERAPAMIL, THEOBROMINE, CALCIUM CHANNEL BLOCKERS