THE PROTECTIVE EFFECT OF SUCRALFATE AND BETAMETHAZONE ON EXPERIMENTAL COLITIS
YALÇIN AKER, HAKKI KÖSE, FERDA KÖKSOY, GÜRSEL SOYBİR, ORHAN YALÇIN
Taksim Hastanesi 1.Cerrahi Kliniği, İSTANBUL
In this experimental study protective effect of sucralfate and betamethazone on colitis formed by %10 acetic acid has been investigated. This study has been conducted on 36 Wistar Albino rats in three groups. Physiologic saline was administered by rectal enema to the control group (n=12), 20%sucratfate to the second group (n=12) and betamethazone in aquous solution to the third (n=12).Experimental colitis was formed after the administration of the drug using 10% acetic acid. The evaluation was made macroscopically by measuring the ulcerated areas (percent of total) and microscopically by measuring the depth of the ulcus.
The result of macroscopic evaluation was 42%(4.43 in the control group, 2%(1.34 in the betamethazone group, and 43%±4.02 in the sucralfate group. Microscopic grading measurements were 3.9±0, 99, 1.0±0.74, 4.4±0.86 respectively.
The analysis of the results revealed that betamethazone's protective effect was highly significant (p<0.001) while sucralfate had (NS) no protective effect.