THE IMPACT OF HIGH BILIRUBIN LEVELS ON FASCIA HEALING
Dr. Tolga MÜFTÜOĞLU, Dr. Erhan BAKIRCIOĞLU, Dr. Abdullah SAĞLAM
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Genel Cerrahi AD, istanbul
Abstract
The aim of this experimental study is to check anastomotic disruption force, after common bile duct ligation and to asses impact of high bilirubin level on fascia healing process.
It has been shown that high bilirubin level has negative effect on fascial healing. Hydroxyproline level in the tissue is known as an indicator of tissue healing. High bilirubin level reduces prolyl hydrolylase enzyme activity and prevents incorparation of proline into collagen.
Sixty Wistar Albino type female rats were randomized into four groups. Group I was control group. Common bile ducts were ligated for 7, 14 and 21 days in group II, III and IV, respectively. Rats were sacrificed at the end of the study and total bilirubin level in blood, hydroxyproline level in fascia and fascial disruption force were determined.
ANOVA test was used for statistical analysis. Total bilirubin level (p<0.001), hydroxyproline level in fascia (p<0.001) and fascial disruption force (p<0.001) were found statistically different in four groups.
We concluded that higher bilirubin levels had negative impact on fascial healing process.
Keywords: bilirubin, fascial healing, hydroxyproline, obstructive jaundice