EFFICACY OF 'ALUMINIUM SULPHATE' IN PREVENTION OF HEPATIC PARENCHYMAL BLEEDING

Abstract

Hepatic parenchymal hemorrhage is a serious problem in major hepatic surgery and after hepatic trauma. The main purpose of emergent intervention in hepatic trauma is to stop hemorrhage. In major hepatic surgery, the mortality rate is 3-14%, and mostly because of bleeding. Although lots of material and technique have been used to stop the bleeding from hepatic parenchyma, the absolute solution of this problem is controversial. In our study, we used "Aluminium Sulphate" (AS) that is never tried before in literature, because of its argumentative effect to stop bleeding by endothelial penetration. We studied on thirty Wistar albino female rats (172±15 g in weight, 5 months of age, outbred). Bleeding model was performed on left lobe of the liver. A gauge washed with %0.9 NaCI in control group and with AS in work group is compressed to the model for three minute. Peri-operative bleeding amount is measured as milliliter. Post-operative bleeding amount is measured by comparing hematocrit values pre and post-operatively.

Per-operative bleeding amounts of control and work group are 2.03+0.83 and 2.13±0.90, respectively (p>0.05). Pre and post-operative hematocrit value difference of groups are 11.20±3.91 and 9.93±4.97, respectively. In his-topathological examination, there was small necrotic areas with sharp range in control group, while large necrotic areas with unsignificiant range are seen in AS group. While, there is less difference between preoperative and posoperative hematocrit value in AS group, the amount of peroperative bleeding is less in control group, but these values are not significant statistically. So, AS is not seemed to be efficient for prevention of hepatic parenchymal bleeding.