The Efficacy of Mebendazol and Albendazol in The Secondary Echinococcosis (Experimental Study)

Abstract

The treatment of Cystic Hydatid disease caused by Echinoccoccus Granulosus is surgical. The most important complication of surgical treatment Is secondary hydatldosis caused by the spillage of cyst content intraabdominally during the manupilation.

Recently, satisfactory results by medical treatment with antihelmintic drugs like Mebendazole and Albendazole has been reported.

In this study, after injection of alive scollces Intraperitonealiy (with 1 ml consisting of 1000 scollces) to 4 weeks-old white mice, they were treated with Mebendazole (40-50 mg/kg/day) and Albendazole (7-10 mg/kg/day) for 35 days.

The percentages of cysts which developed in control Albendazole and Mebendazole groups were 92 %, 59 % and 18 % respectively at autopsy which was performed 5 months later.

There was significant statistical difference according to the number, size and weights of the cysts developed intraperitonealiy between the treated groups with Mebendazole, Albendazole and the control group (p<0.05,p<0.001).

As a therapautic effect of Mebendazole and Albendazole, the growth of secondary cyst hydatidosis has been prevented; Although numerically Mebendazole was more effective than Albendazole, statistically there is no significant difference between them (p>0.05).

Mebendazole and Albendazole therapy is recommended as an adjuvant treatment on post-operative period for the patients which were suspected from the spillage of scolices intraperitonealiy and for the high risk groups of patients with multiple cyst hydatidosis where the surgical therapy contraindicated.