THE EFFECT OF HALOPERIDOL TO CHEMICAL CARCINOGENESIS DEVELOPED BY AZOXYMETHANE IN RAT COLON

Abstract

This experiment is managed in order to detect the effect of haloperidoi - a dopamin antagonist - to experimental carcinogenesis developed by azoxymethane. It is planned to confirm the previous examination results and because of this additional parameters were used. 32 Spraque-Dawley rats were included in this examination. 7.4 mg/kg azoxymethane in isotonic NaCI was injected subcutaneusly to control group once a week for 10 weeks. The experimental group, additional to control ones 2 mg/kg haloperidoi in isotonic NaCI is injected once in two days for 30 weeks. It is observed that chemical carcinogenesis occured with azoxymethane and haloperidoi couldn't prevent chemical carcinogenesis completely, histologically and caused loss of weight by decreasing the caloric intake for rats. There was a positive correlation between weight and the number of rats which became carcinogeneic. Lipid dependent sialic acid levels were high in neoplastic ones ana concluded that this parameter was very useful to diagnose and survey the malign events. So we found that haloperidoi -a dopamin antagonist- coulan't aecrease the rate of azoxymethane indiced carcinogenesis but had a beneficial effect about the tumor marker levels. It is searched the effect of haloperidol to azoxymethane induced carcinogenesis in rats. While haloperidol decreased the tumor marker levels, it couldn't prevent the cancer occurence histologically.