The Effect of Disodium Cromoglycate on Intraabdominal Adhesions and Anastomotic Healing

Abstract

38 rats in two groups, each containing 19 rats, were studied in order to analyse the effects of Disodyum Cromoglycate (DSCG), a mast cell stabiliser, on the intraabdominal adhesions and the healing of anastomosis in this experimental study. Intestinal anastomosis was performed after the caeca/ trauma on all rats. No drug was used in control group (group A). In the study group (group B), 10 mg/kg DSCG was given 30 minutes preoperatively, irrtraoperatively and thereafter on 7th postoperative day all rats were sacrificed, the adhesions were scored macroscopically and evaluated histopathologicalty. The healing of the anastomosis is evaluated by blastic pressure and mast cell degranulation is examined by looking at biopsy materials from the caecums of 4 rats in each group with an electron microscopy. Mann-Whitney U and Wilcoxon Rank-Sum tests were used for statistical correlation. Omental adhesions on the anastomosis line was observed on test subjects. Considering adhesions, there was a significant difference in the group that was given DSCG in comparison to the control group (U=66, p<0.005). It was pointed out that DSCG was a •useful agent on healing of anastomosis (U=172.5p>0.05).