The effects of hyaluronic acid/carboxymethylcellulose membrane on adhesions and anastomotic healing after Hartmann colostomy closure
Ahmet Ender Demirkıran1, Hakan Erpek1, Cumhur Çakır2, Didem Kozacı3, Pars Tunçyürek1
1Adnan Menderes Üniversitesi Tıp Fakültesi Genel Cerrahi AD., Aydın
2Van Devlet Hastanesi Genel Cerrahi Kliniği, Van
3Adnan Menderes Üniversitesi Tıp Fakültesi Biyokimya AD., Aydın
Abstract
The effects of hyaluronic acid/carboxymethylcellulose membrane on adhesions and anastomotic healing after Hartmann colostomy closure
Background: Adhesion formation is one of the leading causes of morbidity after abdominal surgery. In this study, it is aimed to investigate effects of anti-adhesive hyaluronic acid/carboxymethylcellulose membrane on adhesions and anastomotic healing after Hartmann colostomy closure in a rat model.
Materials and Methods: Thirty male Wistar-Albino rats are randomised into 3 groups: Standard colostomy (Grup A), standart colostomy + hyaluronic acid/carboxymethylcellulose (Grup B), and control group (Grup C). Adhesions were evaluated by means of a scoring system. Bursting pressure values, and hydroxyproline levels were detected.
Results: Adhesion score of group A (1.7±0.6) was statistically higher compared to group B (1.1±0.3), and to control group C (1.2±0.4) (p<0.05). There was no statistical difference between bursting pressure values, and hydroxyproline levels.
Conclusions: Although hyaluronic acid/carboxymethylcellulose membrane decreased adhesion formation, there was no obvious effect on anastomotic strength and healing. On the other hand, further clinical studies are needed to draw major conclusions.
Keywords: Hyaluronic acid/carboxymethylcellulose, adhesion, colostomy closure