A new practice of trichloroaceticacid peeling: reduction of second primary skin cancer
Gülden Avcı1, Tayfun Akoz2, Aylin Ege Gül3
1Çanakkale Onsekiz Mart Üniversitesi, Plastik ve Rekonstrüktif Cerrahi, Çanakkale
2Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Plastik ve Rekonstrüktif Cerrahi, İstanbul
3Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Patoloji, İstanbul
Purpose: Exposure to solar radiation is a major cause of nonmelanoma skin cancer. Topical application of chemical peeling agents to reverse actinic damage of skin is a well-established, accepted clinical practice. Subclinic malignant lesions are generally seen with skin cancers simultaneously. In this paper, we evaluated effectiveness of the tricholoroacetic acid peeling to treatment of subclinic lesions.
Material and Methods: Between 1999 and 2004, 102 patients with skin cancer were treated surgically. In addition to the surgical treatment of malignant lesions, full-face chemical peeling with 35-40% trichloroacetic acid was applied during the same operative session to 48 patients whose faces had extensively sun-damaged skin. The ages of patients were varied between 51 and 93. They were followed- up 1-5 years. The effectiveness of the TCA treatment was evaluated with pathologic examinations.
Result: Second primary skin cancer was observed in only 3 patients who were applied TCA peeling. TCA peeling causes histologic changes such as correction of epidermal atrophy and atypia as well as deposition of new subepidermal collagen.
Conclusion: Trichloroaceticacid peeling provides a prophylactic effect against the development of skin malignancies.
Keywords: Chemical peeling, skin cancer, trichloroaceticacid