EXPERIMENTAL COLITIS

Original Article

EXPERIMENTAL COLITIS

Turk J Surg 1993;9(1):22-25
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Abstract

Protective effect of Desferrioxamine, Disulfiram, Superoxide Dismutase (SOD) and Catalase (CAT) on experimental colitis induced by 4% acetic acid has been investigated in this experimental study. 30 Wistar Albino rats have been divided in to 5 groups. No drug was given to the control group. The second group was given Desferrioxamine, third group disulfiram, fourth group SOD, fifth group SOD+CAT. Analysis of the results revealed significant cytoprotection by desferrioxamine which as a iron chelating agent, anda by Disutfiram, while SOD and Catalase has been found to be ineffective.

Keywords: EXPERIMENTAL COLITIS, DESFERRIOXAMINE, DISULFIRAM, SUPEROXIDE DISMUTASE, CATALASE